Mesotherapy is a method that injects vitamins, minerals, antioxidants and other active substances directly into the third layer of the skin where the blood vessels are, the mesoderm. Mesotherapy provides an intensive hydration and nutrition of the skin itself, and the ageing process is significantly slowed down.

First use of mesotherapy was with the purpose of pain reduction. Mesotherapy was first used by M. Pistor in 1952 in France. After his work was published mesotherapy was used for cellulite, and fat reduction and to improve nourishment and the looks of skin.

As we grow older the skin goes through changes such as texture and elasticity loss, unequal pigmentation, loss of subdermal fatty tissue and the skin has worse circulation, the skin becomes prominent with enlarged capillaries. Most of the listed changes come with the reduced function of fibroblast, UV Sun radiation influence, free radicals, harmful influences from the environment. Applying the antioxidants, vitamins, amino acids into the middle layer of the skin enables direct supply to the blood vessels with all the required ingredients.

How does mesotherapy affect the skin?

The surface layer of the skin functions like a barrier to the substances from the environment, which protects our organism but also prevents the resorption of more than 10% of the active substances that exist in regenerative creams.

The goal of mesotherapy in the skin rejuvenation process is to increase the activities of fibroblast, cells responsible for production of collagen, elastin and hyaluronan in the skin, and to apply full concentration of active substances necessary to regenerate healthy and youthful skin. With repeated procedures the depth of the wrinkles is reduced, the amount of collagen is increased and therefore the skin tone is improved.

What substances are used in mesotherapy?

Sterile substances that contain one active substance – hyaluronic acid, vitamin C, vitamin A, amino acids, or cocktails with the listed substances depending on the goal we wish to achieve. More about mesotherapy with hyaluronic acid read here.

What does a mesotherapy treatment look like?

Facial therapy is usually performed in 3 to 4 treatments. Depending on the materials used, the treatments can be from 1 to 2 weeks or one month apart. Maintenance can be performed once every two months or with a repeated series of treatments after 6 to 8 months. The procedure itself  consists of applying sterile cocktails by miniature pricks (up to 2 mm in depth) on every centimeter of the skin surface.


On what body parts is mesotherapy performed?

Mesotherapy is performed on the face, neck, cleavage, hands or thighs. Another important indication for mesotherapy is reduction in cellulite. Substances that melt the fat, increase the circulation, enable better drainage or have diuretic properties are used then.

How many mesotherapy treatments are required for cellulite reduction?

It takes from two to three mesotherapy treatments to see the result. The number of treatments is individual and depends on the age, treated region, and the habits of the patients (smoking, exposure to solar radiation). After a series of 8 to 10 treatments, reduction in cellulite is significant and the skin becomes more firm and healthy.

Are mesotherapy and lipolysis the same procedure?

Mesotherapy and lipolysis are two different procedures and are often combined to provide a satisfactory effect. Cellulite mesotherapy is ideal to perform in winter period for the body to be at its most beautiful when swimsuit season comes.

What are the contraindications for the mesotherapy treatment?

Mesotherapy contraindications are: autoimmune diseases, blood clotting disorder, pregnancy, diabetes mellitus, bacterial skin infections.

Mesotherapy can be an outstanding complement to other aesthetic procedures such as treatment with hyaluronic acid, botox procedure, chemical peels, surgical lifts, and with regular treatments the time for using aggressive surgical methods is significantly delayed.

Spec. Dr. Svetlana Djurisic, dermatologist
Dermatological clinic DERMATIM